Research

Reginald McGee 2014 Purdue Graduate Research Day

Reginald McGee 2016 BAMM!

I completed my Ph.D. at Purdue University, where I worked under the supervision of Dr. Greg Buzzard. My thesis focused on using dynamical systems to model B cell antigen receptor signaling pathways and proving a convergence result when using a model-based experimental design criteria.

My postdoctoral fellowship is co-sponsored by Dr. Kevin R. Coombes in the Department of Biomedical Informatics, which is housed in the OSU Wexner Medical Center.

My main research interest as a postdoc is using mathematical modeling and novel data analysis methods to improve understanding of leukemia, a cancer that leads to a large number of irregular, immunologically-ineffectual immune cells in the blood. Presently, I am using acute myeoloid leukemia (AML) CyTOF data to identify biomarkers that are characteristic in subgroups of AML. The structure of this dataset allows one to determine specific populations of leukemic cells and consider marker variation within those populations. Also on the data analysis horizon, I plan to begin an AML project considering mutant allele frequency data soon. Additionally, I am interested in modeling the progression of the chronic lymphocytic leukemia and how the signaling pathways in leukemic cells become resistant to targeted therapies. As time permits, I would also like to look into modeling aspects of autoimmune responses.

My CV (last updated 5/2018) can be found above.

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