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GYÖRGY TARCZAY, GÁBOR MAGYARFALVI AND ELEMÉR VASS, Institute of Chemistry, Eötvös University, H-1518 Budapest 112, P.O. Box 32, Hungary.
It is shown on the examples of R-2-amino-1-propanol and N-acetyl-L-alanyl-N-methylamide that matrix isolation vibrational circular dichroism spectroscopy is a useful method for simultaneous determination of the conformational distribution and absolute configuration of molecules with multiple conformers capable of strong intermolecular interactions, especially hydrogen-bonds. The technique could also be utilized for the characterization of reactive chiral species or weakly bound complexes of chiral molecules.