PURPOSE: Use methylation profiles and clinical variables to group
tumor samples into clusters and then organize them into a tree to
represent tumor progression pathways that conform to strict heritability.
Software (in a zipped, tar file)
Instructions for the heritable clustering algorithm.
- Wang, Z., Yan, P., Potter, D., Eng, C., Huang, T.H., Lin, S. (2005)
Algorithms - Recapitulation of Breast Tumor Progression Pathways Using DNA
- Supplementary Material
TableS1: Determination of Number of Clusters
FigureS1: Pathway tree based on hierarchical clustering
FigureS2: Pathway tree based on K-Means
FigureS3: Pathway tree based on PAM
FigureS4: Pathway tree based on likelihood
FigureS5: Pathway tree based on likelihood (including 7 incomplete samples)