Wu Lab


The long-term goal of our laboratory is to understand the roles of cytoskeletal and signaling proteins in cellular asymmetry and cell division in normal and cancer cells. In the near term, we are focusing on the molecular mechanisms of cytokinesis in the fission yeast S. pombe using a combination of cellular, molecular, biochemical, genetic, and microscopic approaches.
Actin filaments connect myosin nodes together to form a network during contractile-ring formation in cells expressing GFP-CHD(Calponin Homology Domain of IQGAP Rng2p) and myosin light chain Rlc1p-mRFP1. The assembly of the contractile ring in fission yeast cells expressing GFP-tagged Myo2p and a Spindle Pole Body (SPB, an equivalent of the centrosome) marker Sad1p-GFP. The small dots are Myo2p nodes and the bright spots are SPBs.